Minnelide/Triptolide (TL) has recently emerged as a potent anticancer drug in non-small cell lung cancer (NSCLC).However, the precise mechanism of its action remains ambiguous.In this study, we elucidated the molecular basis for TL-induced cell death in context to p53 status.Cell death was attributed to dysfunction of mitochondrial bioenergetics in
Abstract Background Secondary aortoenteric fistula is a rare but fatal complication after reconstructive surgery for an aortic aneurysm characterized by abdominal pain, fever, hematochezia, and hematemesis, and the mortality rate is high.It has been suggested that it arises due to either continuous physical stimulation or prosthesis infection durin
Michael E Schatman,1 Beth D Darnall21Foundation for Ethics in Pain Care, Bellevue, WA, USA; 2Stanford University School of Medicine, Division of Pain Medicine, Palo Alto, CA, USAAbuse-deterrent formulations (ADFs) of opioids have been in existence since the 1970s,1 with abuse-deterrent mechanisms including physical barriers (eg, barriers to AEG DUK
Abstract Light exposure triggers a range of physiological and behavioural responses that can improve and challenge health and well-being.Insights from laboratory Posts studies have recently culminated in standards and guidelines for measuring and assessing healthy light exposure, and recommendations for healthy light levels.Implicit to laboratory p
This report elaborates on adaptations of the eyes of the whale shark Rhincodon typus (Elasmobranchii, Wheel Axle Rhincodontidae), including the discovery that they are covered with dermal denticles, which is a novel mechanism of eye protection in vertebrates.The eye denticle differs in morphology from that of the dermal denticles distributed over t